What it does

Psilocybin is converted in the body to psilocin, a serotonergic psychedelic. Effects last 4–6 hours. Currently studied in clinical trials for depression and end-of-life distress.

Safer-use principles

• —Set and setting. Sober sitter. Comfortable space. No plans.
• —Personal or family history of psychosis or bipolar disorder is a strong contraindication.
• —Species and potency vary enormously — 'a gram' means very different things across mushrooms.
• —Wait at least 2 weeks between experiences; tolerance builds fast.

Dangerous combinations

Combining with SSRIs, lithium, or tramadol is discouraged. Stimulants intensify anxiety. Alcohol dulls and destabilizes the experience.

If something goes wrong

Fatal overdose from psilocybin alone is not established. Difficult trips are best handled with calm reassurance, a change of scene, water, and time. Persistent symptoms after wearing off need medical care.