What it does

LSD is a long-acting serotonergic psychedelic. Effects last 8–12 hours. It profoundly alters perception, emotion, and thinking. Physiologically it is among the least toxic recreational substances, but psychologically it can be intense.

Safer-use principles

• —Set and setting matter more than any other variable. Trusted people, safe place, no obligations.
• —Have a sober trip sitter — especially your first few times.
• —Personal or family history of psychosis or bipolar disorder is a strong contraindication.
• —Test what you have. Blotters and liquid are often counterfeit; NBOMe compounds sold as LSD are dangerous.

Dangerous combinations

LSD + lithium or tramadol is linked to seizures. LSD + MAOIs is unpredictable. Stimulants amplify anxiety loops.

If something goes wrong

Fatal overdose from LSD alone is essentially unknown. Difficult experiences are best handled by changing environment, reassurance, calm music, and time. Persistent psychiatric symptoms after the drug wears off need medical care.